Ga-68-Trivehexin enables PET/CT imaging of carcinomas in humans by targeting the "cancer integrin" αvβ6Re

Neil G. Quigley1, Katja Steiger1, Sebastian Hoberück2, Norbert Czech3, Maximilian A. Zierke1, Susanne

Kossatz4, Marc Pretze2, Frauke Richter1, Wilko Weichert1, Christian Pox5, Jörg Kotzerke2, Johannes Notni1, 6

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Research Area A10


Expression of the TGF-β activating cell adhesion receptor αvβ6-integrin is closely related to cancer malignancy, since it drives invasion and metastasis. αvβ6-integrin is found in high density on tumor cells especially of pancreatic ductal adenocarcinoma (PDAC) [1], but also squamous cell-, cervical-, lung adeno-, and other carcinomas as well as fibrotic diseases (idiopathic pulmonary fibrosis, IPF). Sensitive probes for clinical imaging of αvβ6-integrin are thus highly desirable.