Imaging pH, metabolism and hypoxia using hyperpolarized C-MRI and [18F]FMISO-PET to assess metabolic connectivity and heterogeneity of the tumor microenvironment in glioblastoma

Martin Grashei1, Carolin Kitzberger2, Jason G. Skinner1, Sandra Sühnel1, Geoffrey J. Topping1,
Elisabeth Bliemsrieder1, Christian Hundshammer1, Katja Steiger3, Rainer Glass4, Wolfgang
Weber1, Christine Spitzweg2, Franz Schilling1

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Research Area A7


Glioblastoma (GBM) is a highly malignant and heterogeneous tumor of the central nervous
system. Despite a large variety of existing treatment approaches1, prognosis and outcome
are still devastating. However, therapy efficacy often depends on the tumor
microenvironment such as extracellular pH and oxygenation and is often driven by tumor
metabolism. Here, we studied GBM by multimodal imaging of pH2,3, pyruvate-lactate
conversion and hypoxia using hyperpolarized (HP) 13C-MRI and 18F-PET to investigate links
between hypoxia, pH and lactate production in these tumors.