[18F]FLT IS SUPERIOR TO [18F]FDG FOR PREDICTING EARLY RESPONSE TO ANTIPORLIFERATIVE TREATMENT IN HIGH-GRADE LYMPHOMA IN A DOSE-DEPENDENT MANNER


Nicolas Graf, Ken Herrmann, Barbara Numberger, Daniela Zwisler, Michaela Aichler, Annette Feuchtinger, Tibor Schuster, Hans-Jürgen Wester, Reingard Senekowitsch-Schmidtke, Christian Peschel, Markus Schwaiger, Ulrich Keller, Tobias Dechow, Andreas K. Buck. (05-10-2012).

Springer Link201240:34–43, Eur J Nucl Med Mol Imaging

Department: 

Research Area C

Abstract: 

Purpose Positron emission tomography (PET) with the thymidine analogue [18F]fluorothymidine ([18F]FLT) has been shown to detect early response to chemotherapy in highgrade lymphoma. In this preclinical in vitro and in vivo study we compared [18F]FLT to the glucose analogue [18F] fluorodeoxyglucose ([18F]FDG) regarding dose-dependent visualization and prediction of early therapy response.