ALDH1A1 EXPRESSION INCREASES IN RECURRENT GLIOBLASTOMA PATIENTS AND PREDICTS A CHEMORESISTANT PHENOTYPE
Fabian Schneider, Sandra Baur, Jürgen Schlegel, Bernhard Meyer, Florian Ringel. (30-11-2014).
Technische Universität München & Klinikum Rechts der Isar der Technischen Universität München, 2015Department:
Research Area B
Abstract:
Glioblastomas (GBM) are the most common brain tumors in humansandare effectively incurable. The defining hallmarks of the aggressiveness of GBMarelocal invasion and neo-angiogenesis. Limited efficacy of patient treatmentstrategiesis due to rapid invasion of surrounding tissue and the fast appearance of chemo-andradioresistant tumor cells often termed cancer stem cells (CSC). Our laboratoryhasrecently shown that Aldehyde Dehydrogenase 1 A1 (ALDH1A1) expressing GBM cells show a CS Cphenotype and a nincreased resistance to Temozolomid (TMZ) compared to ALDH1A1 negative cells.
