HSP70 INTERACTIONS WITH MEMBRANE LIPIDS REGULATE CELLULAR FUNCTIONS IN HEALTH AND DISEASE
Zsolt Balogia, Gabrielle Multhoffc, Thomas Kirkegaard Jensend, Emyr Lloyd-Evanse, Tetsumori Yamashimaf, Marja Jäätteläg, John L. Harwoodh, László Víghi. (30-01-2019).Elsevier Ltd., 2019
Research Area B
Beyond guarding the cellular proteome the major stress inducible heat shock protein Hsp70 has been shown to interact with lipids. Non-cytosolic Hsp70 stabilizes membranes during stress challenges and, in pathophysiological states, facilitates endocytosis, counteracts apoptotic mechanisms, sustains survival pathways or represents a signal that can be recognized by the immune system. Disease-coupled lipid-associated functions of Hsp70 may be targeted via distinct subcellular localizations of Hsp70 itself or its specific interacting lipids. With a special focus on interacting lipids, here we discuss localization-dependent roles of the membranebound Hsp70 in the context of its therapeutic potential, particularly in cancer and neurodegenerative diseases.